You are hereby invited to the Workshop on the Cocktail effects of environmental pollutants on human and wildlife health in the northern Norway and Arctic regions
NILU - Norwegian Institute for Air Research, Norwegian Institute for Water Research (NIVA) and University of Tromsø (UiT) is assigned to lead a workshop of the flagship “Contaminants” in the Fram Centre. The two day workshop will be held at the FRAM - High North Research Centre for Climate and the Environment (Fram Centre), Tromsø, 21-22 March, 2013.
Participants should register to mikael.harju@nilu.no no later than 15.03.2013.
We hope that Fram Centre members and other invited researchers planning to attend the workshop can prepare a short 5 min presentation of their organisations interest and current research on this topic. This is mainly as an update for the round-table discussions on experiments and actions for the years to come.
Principal objectives and goals of the workshop
The main goal of this network meeting is to develop a good basis for collaboration and communication and develop a partnership between research groups within in vitro and in vivo toxicology, in silico receptor modeling, toxicogenomics, predictive modeling, environmental monitoring and research of Arctic wildlife and human health. The goal is to develop future proposals into the effects of cocktail mixtures in the Arctic region and thereby further develop collaborations between Fram Centre participants and international collaborators.
Programme:
THURSDAY
10:00 Welcome
10:05 – 12:00 Presentations by invited speakers
Andreas Kortenkamp, Brunel University (UK)
Mixture toxicology – state of the art in human and ecological cumulative risk assessment
Karina Petersen, NIVA (NO)
Combined toxicity assessment in small scale and in vitro experimental models
Thomas Backhaus, University of Gøteborg (SE)
The threshold of (eco)toxicological concern (TTC) - a suitable tool for mixture risk assessment and ranking?
12:00 – 12:30 Lunch
12:30 – 14:30 Presentations continue
Johan Trygg, Umeå University (SE)
Chemometrics and metabolomics to study complex biological systems
Anita Evenset, Akvaplan-niva, Framsenteret (NO)
Environmental monitoring in the Arctic – The Bjørnøya study
Ragna Bogen Hetland, Norwegian Institute of Public Health/VKM (NO)
Risk assessments of combined exposures to chemicals by VKM
14:30 – 14:45 Short break
14:45 – 17:00 Short presentations by invited speakers and partners
FRIDAY
09:00 – 12:00 Discussions of the seven areas of development below
12:00 – 12:30 Lunch
12:30 – 14:00 Summary and future aspects
Basis of the workshop will be to discuss:
Development of experimental protocols and mixtures such as:
- Presentation of different approaches to address combined toxicity and multiple stressors
- Statistical design to limit the amount of studies and define standard mixtures for testing
- Suggest protocols on how to test mixtures both in vitro and in vivo
- Identify strategies for the use of surrogate species versus Arctic experimental models
- Elucidate the effects of defined standard mixtures on in vitro models representing different toxic endpoints
- Data compilation and evaluation of data to address the biological complexity and systems affected
- How can combined toxicity be implemented in hazard and risk assessment procedures?
- How to expand laboratory studies to ecological relevant exposure scenarios (e.g. linkage with biomonitoring/ecological monitoring) efforts
This workshop is financed by incentive funds to the Fram Centre, flagship “Contaminants-effects on ecosystem and health”.
The applicants for the proposal “Cocktail effects of environmental pollutants to human and wildlife health in the northern Norway and arctic regions”:
Project leader/Institute: Mikael Harju/NILU - Norwegian Institute for Air Research
Co applicants:
NILU/University of Tromsø: Torkjel Sandanger
Norwegian Polar institute: Heli Routti
NIVA: Knut Erik Tollefsen
International and national partners
University of Tromsø (Norway): Ingebrigt Sylte
Umeå University (Sweden): Johan Trygg
UFZ (Germany): Rolf Altenburger